.
Jensen Ackles as Billy Grant

Nikki Blonsky as Janet Trewednack

Amanda Bynes as Lulu Lefkowitz

Glenn Close as Gladys McGillicuddy

Zac Efron as Perry Pines

Sarah Michelle Gellar as Holly Holbrook

Marcia Gay Harden as Doris Daley

Anne Hathaway as Kathy Kittredge

Jennifer Hudson as Hattie Hayes

Felicity Huffman as Principal Milfred Klump

Scarlett Johansson as Marlene Konstadt

Eric Johnson as Elliot Buckley

January Jones as Nancy Beardsley

Vincent Kartheiser as Gus Quigg

Stacy Keach as Commissioner Leonard Lemon

Queen Latifah as Hepsie Hayes

Rose McGowan as Ginny Giglione

Ewan McGregor as Broderick 'Brody' Batson

Tobey Maguire as Alvin Appleby

Bette Midler as Patty Pickford

Elisabeth Moss as Dot Spaulding

Jared Padalecki as Dino Bucco

Hayden Panettiere as Peggy Pickford

John Slattery as Bradford Beardsley

Brittany Snow as Gloria McGillicuddy

Channing Tatum as Sammy DiMucci

Milo Ventimiglia as Kentucky Zbornak

Tom Welling as Freddy Fogarty

and

Reese Witherspoon as Vicki Skinridge
.